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ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1A1) Antibody

Catalogue No: abx000792
Price: £120.00
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ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1A1) Antibody ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1A1) Antibody

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ATP1A1 Antibody is a Rabbit Polyclonal antibody against ATP1A1. The Na,K-ATPase is an integral membrane heterodimer belonging to the P-type ATPase family. This ion channel uses the energy derived from ATP hydrolysis to maintain membrane potential by driving sodium export and potassium import across the plasma membrane against their electrochemical gradients. It is composed of a catalytic α subunit and a β subunit (reviewed in 1). Several phosphorylation sites have been identified for the α1 subunit. Tyr10 is phosphorylated by an as yet undetermined kinase (2), Ser16 and Ser23 are phosphorylated by PKC, and Ser943 is phosphorylated by PKA (3-5). All of these sites have been implicated in the regulation of enzyme activity in response to hormones and neurotransmitters, altering trafficking and kinetic properties of Na,K-ATPase. Altered phosphorylation in response to angiotensin II stimulates activity in the rat proximal tubule (6). Na,K-ATPase is also involved in other signal transduction pathways. Insulin regulates its localization in differentiated primary human skeletal muscle cells, and this regulation is dependent on ERK1/2 phosphorylation of the α subunit (7). Na,K-ATPase and Src form a signaling receptor complex that affects regulation of Src kinase activity and, subsequently, its downstream effectors (8,9).

Target ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1A1)
Clonality Polyclonal
Reactivity Human
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein of human ATP1A1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P05023 (UniProt, ExPASy)
UniProt Entry Name AT1A1_HUMAN
Gene Symbol ATP1A1
GeneID 476
KEGG hsa:47
String 9606.ENSP00000445306
Molecular Weight Calculated MW: 74 kDa, 109 kDa, 112 kDa, 113 kDa
Observed MW: 113 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1A1) Antibody

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