V-Type Proton ATPase Catalytic Subunit A (ATP6V1A) Antibody

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues.

Target	V-Type Proton ATPase Catalytic Subunit A (ATP6V1A)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 441-468 amino acids from the Central region of human ATP6V1A.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P38606 (UniProt, ExPASy)
UniProt Secondary AC	B2RBR8, B7Z1R5, D3DN75, Q53YD9, Q96DY6, Q9UHY3
UniProt Entry Name	VATA_HUMAN
Gene Symbol	ATP6V1A
KEGG	hsa:523
String	9606.ENSP00000273398
Molecular Weight	Calculated MW: 68.3 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Cow and Pig ATP6V1A.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on V-Type Proton ATPase Catalytic Subunit A (ATP6V1A)

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