V-Type Proton ATPase Subunit B, Brain Isoform (ATP6V1B2) Antibody

ATP6V1B2 Antibody is a Rabbit Polyclonal antibody against ATP6V1B2. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts.

Target	V-Type Proton ATPase Subunit B, Brain Isoform (ATP6V1B2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 262-511 of human ATP6V1B2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P21281 (UniProt, ExPASy)
UniProt Secondary AC	B2R5Z3, D3DSQ5, Q14544, Q15859, Q96IR0
UniProt Entry Name	VATB2_HUMAN
Gene Symbol	ATP6V1B2
GeneID	526
OMIM	124480
NCBI Accession	NP_001684.2
HGNC	854
KEGG	hsa:526
Ensembl	ENSG00000147416
String	9606.ENSP00000276390
Molecular Weight	Calculated MW: 57 kDa Observed MW: 57 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on V-Type Proton ATPase Subunit B, Brain Isoform (ATP6V1B2)

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