AURKA Antibody is a Rabbit Polyclonal antibody against AURKA. Aurora A (AIK) is a cell cycle-regulated Ser/Thr protein kinase that is overexpressed in many tumor cell lines. Phosphorylation of Aurora A at Thr288 within the kinase activation loop results in a significant increase in its activity and may target the protein for proteasomal degradation during mitosis. The closely-related kinase Aurora B (AIM1) has been implicated in multiple mitotic events, and siRNA silencing of Aurora B expression results in reduced histone H3 phosphorylation, aberrant chromosome alignment/segregation, and altered survivin localization.
| Target |
Aurora Kinase A (AURKA) |
| Clonality |
Polyclonal |
| Reactivity |
Human, Mouse |
| Tested Applications |
WB |
| Host |
Rabbit |
| Recommended dilutions |
WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation |
Unconjugated |
| Immunogen |
A synthetic peptide of human AURKA. |
| Isotype |
IgG |
| Form |
Liquid |
| Purification |
Affinity purified. |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC |
O14965 (UniProt,
ExPASy)
|
| UniProt Secondary AC |
E1P5F9, O60445, O75873, Q9BQD6, Q9UPG5 |
| UniProt Entry Name |
AURKA_HUMAN |
| Gene Symbol |
AURKA |
| GeneID |
6790
|
| KEGG |
hsa:6790
|
| String |
9606.ENSP00000216911
|
| Molecular Weight |
Calculated MW: 45 kDa
Observed MW: 46 kDa |
| Buffer |
PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |
| Concentration |
7.97 mg/ml |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
Research Articles on Aurora Kinase A (AURKA) Antibody
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