Aurora Kinase A (AURKA) Antibody

AURKA Antibody is a Rabbit Polyclonal antibody against AURKA. Aurora A (AIK) is a cell cycle-regulated Ser/Thr protein kinase that is overexpressed in many tumor cell lines. Phosphorylation of Aurora A at Thr288 within the kinase activation loop results in a significant increase in its activity and may target the protein for proteasomal degradation during mitosis. The closely-related kinase Aurora B (AIM1) has been implicated in multiple mitotic events, and siRNA silencing of Aurora B expression results in reduced histone H3 phosphorylation, aberrant chromosome alignment/segregation, and altered survivin localization.

Target	Aurora Kinase A (AURKA)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 301-403 of human AURKA.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O14965 (UniProt, ExPASy)
UniProt Secondary AC	E1P5F9, O60445, O75873, Q9BQD6, Q9UPG5
UniProt Entry Name	AURKA_HUMAN
Gene Symbol	AURKA
GeneID	6790
NCBI Accession	NP_003591.2
KEGG	hsa:6790
String	9606.ENSP00000216911
Molecular Weight	Calculated MW: 46 kDa Observed MW: 46 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	7.97 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Aurora Kinase A (AURKA)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue