Aurora Kinase A (AURKA) Antibody

Catalogue No: abx001733
Price: £120.00
(Size: 20 µl)
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AURKA Antibody is a Rabbit Polyclonal antibody against AURKA. Aurora A (AIK) is a cell cycle-regulated Ser/Thr protein kinase that is overexpressed in many tumor cell lines. Phosphorylation of Aurora A at Thr288 within the kinase activation loop results in a significant increase in its activity and may target the protein for proteasomal degradation during mitosis. The closely-related kinase Aurora B (AIM1) has been implicated in multiple mitotic events, and siRNA silencing of Aurora B expression results in reduced histone H3 phosphorylation, aberrant chromosome alignment/segregation, and altered survivin localization.

Target Aurora Kinase A (AURKA)
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human AURKA.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O14965 (UniProt, ExPASy)
UniProt Secondary AC E1P5F9, O60445, O75873, Q9BQD6, Q9UPG5
UniProt Entry Name AURKA_HUMAN
Gene Symbol AURKA
GeneID 6790
KEGG hsa:6790
String 9606.ENSP00000216911
Molecular Weight Calculated MW: 45 kDa
Observed MW: 46 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration 7.97 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Aurora Kinase A (AURKA)

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