Aurora Kinase A (AURKA) Antibody

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Catalogue No: abx001733
Price: US$217.50
(Size: 20 µl)

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Aurora Kinase A (AURKA) Antibody Aurora Kinase A (AURKA) Antibody

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Datasheet SDS
AURKA Antibody is a Rabbit Polyclonal antibody against AURKA. Aurora A (AIK) is a cell cycle-regulated Ser/Thr protein kinase that is overexpressed in many tumor cell lines. Phosphorylation of Aurora A at Thr288 within the kinase activation loop results in a significant increase in its activity and may target the protein for proteasomal degradation during mitosis. The closely-related kinase Aurora B (AIM1) has been implicated in multiple mitotic events, and siRNA silencing of Aurora B expression results in reduced histone H3 phosphorylation, aberrant chromosome alignment/segregation, and altered survivin localization.

Target Aurora Kinase A (AURKA)
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications ELISA, WB, IF/ICC
Host Rabbit
Recommended dilutions ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic peptide corresponding to AURKA. The exact sequence is proprietary.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O14965 (UniProt, ExPASy)
UniProt Secondary AC E1P5F9, O60445, O75873, Q9BQD6, Q9UPG5
UniProt Entry Name AURKA_HUMAN
Gene Symbol AURKA
GeneID 6790
OMIM 603072
NCBI Accession NP_003591.2
HGNC 11393
KEGG hsa:6790
Ensembl ENSG00000087586
String 9606.ENSP00000216911
Molecular Weight Calculated MW: 46 kDa
Observed MW: 46 kDa
Buffer PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration 7.97 mg/ml
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on Aurora Kinase A (AURKA)


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