Axin-2 (AXIN2) Antibody

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

Target	Axin-2 (AXIN2)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 816-843 amino acids from the C-terminal region of human AXIN2.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9Y2T1 (UniProt, ExPASy)
UniProt Secondary AC	Q3MJ88, Q9H3M6, Q9UH84
UniProt Entry Name	AXIN2_HUMAN
Gene Symbol	AXIN2
GeneID	8313
OMIM	114500
HGNC	904
Ensembl	ENSG00000168646
String	9606.ENSP00000302625
Molecular Weight	Calculated MW: 93.6 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Rat AXIN2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Axin-2 (AXIN2)

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