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Axin-2 (AXIN2) Antibody

Catalogue No: abx001955
Price: £120.00
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Axin-2 (AXIN2) Antibody

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Axin-2 (AXIN2) Antibody is a Rabbit Polyclonal antibody against Axin-2 (AXIN2). The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

Target Axin-2 (AXIN2)
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human AXIN2.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q9Y2T1 (UniProt, ExPASy)
UniProt Secondary AC Q3MJ88, Q9H3M6, Q9UH84
UniProt Entry Name AXIN2_HUMAN
Gene Symbol AXIN2
GeneID 8313
OMIM 114500
HGNC 904
Ensembl ENSG00000168646
String 9606.ENSP00000302625
Molecular Weight Calculated MW: 93 kDa
Observed MW: 85 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Axin-2 (AXIN2) Antibody

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