Tyrosine-Protein Kinase Receptor UFO (AXL) Antibody
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Catalogue No: abx011796
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US$427.75
(Size: 100 µl)
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Datasheet SDS
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, the Axl protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduce signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation. This receptor can also mediate cell aggregation by homophilic binding. Axl is a chronic myelogenous leukemia-associated oncogene and also associated with colon cancer and melanoma. It is in close vicinity to the bcl3 oncogene which is at 19q13.1-q13.2. The Axl gene is evolutionarily conserved between vertebrate species. This gene has two different alternatively spliced transcript variants.
Research Articles on Tyrosine-Protein Kinase Receptor UFO (AXL)
| Target | Tyrosine-Protein Kinase Receptor UFO (AXL) |
| Research Area | Enzymes and Kinases |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of AXL (aa466-530) expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P30530 (UniProt, ExPASy) |
| UniProt Secondary AC | Q8N5L2, Q9UD27 |
| UniProt Entry Name | UFO_HUMAN |
| Gene Symbol | AXL |
| GeneID | 558 |
| OMIM | 109135 |
| HGNC | 905 |
| KEGG | hsa:558 |
| Ensembl | ENSG00000167601 |
| String | 9606.ENSP00000301178 |
| Enzyme Commission Number | EC 2.7.10.1 |
| Molecular Weight | 97.4 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |