B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain (CD79A) Antibody
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Catalogue No: abx148556
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US$420.50
(Size: 100 µg)
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Datasheet SDS
B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain (CD79A) Antibody is a Rabbit Polyclonal antibody for the detection of CD79A. Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro-and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
Research Articles on B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain (CD79A)
| Target | B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain (CD79A) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | CD79a molecule, immunoglobulin-associated alpha |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P11912 (UniProt, ExPASy) |
| UniProt Secondary AC | A0N775, Q53FB8 |
| UniProt Entry Name | CD79A_HUMAN |
| Gene Symbol | CD79A |
| GeneID | 973 |
| OMIM | 112205 |
| HGNC | 1698 |
| KEGG | hsa:973 |
| Ensembl | ENSG00000105369 |
| String | 9606.ENSP00000221972 |
| Molecular Weight | Observed MW: 40 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |