Beta-Secretase 1 (BACE1) Antibody
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Catalogue No: abx033673
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US$326.25
(Size: 80 µl)
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Datasheet SDS
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is bACE1. This protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.
Research Articles on Beta-Secretase 1 (BACE1)
| Target | Beta-Secretase 1 (BACE1) |
| Research Area | Neuroscience |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 476-501 amino acids from human BACE. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P56817 (UniProt, ExPASy) P56818 (UniProt, ExPASy) |
| UniProt Secondary AC | A0M8W7, B0YIU9, E9PE65, H7BXJ9, Q9BYB9, Q9BYC0, Q9BYC1, Q9UJT5, Q9ULS1 |
| UniProt Entry Name | BACE1_HUMAN |
| Gene Symbol | BACE1 |
| GeneID | 23621 |
| OMIM | 604252 |
| HGNC | 933 |
| KEGG | hsa:23621 |
| Ensembl | ENSG00000186318 |
| String | 9606.ENSP00000318585 |
| Molecular Weight | Calculated MW: 55.8 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rat and Cow BACE1. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |