Bak (BH3 Domain Specific) Antibody

BAK belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BAK localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.

Target	Bak (BH3 Domain Specific)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/2000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 56-91 amino acids from human Bak.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q16611 (UniProt, ExPASy)
UniProt Secondary AC	C0H5Y7, Q6I9T6, Q92533
UniProt Entry Name	BAK_HUMAN
KEGG	hsa:578
String	9606.ENSP00000363591
Molecular Weight	Calculated MW: 23.4 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Bak (BH3 Domain Specific)

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