Bcl-2 Homologous Antagonist/Killer (BAK1) Antibody

BAK1 Antibody is a Rabbit Polyclonal antibody against BAK1. The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.

Target	Bcl-2 Homologous Antagonist/Killer (BAK1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC, IP
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200, IP: 0.5-4 µg/200-400 µg whole cell extracts. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Bak.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q16611 (UniProt, ExPASy)
UniProt Secondary AC	C0H5Y7, Q6I9T6, Q92533
UniProt Entry Name	BAK_HUMAN
Gene Symbol	BAK1
GeneID	578
NCBI Accession	NP_001179.1
KEGG	hsa:578
String	9606.ENSP00000363591
Molecular Weight	Calculated MW: 23 kDa Observed MW: 25 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Bcl-2 Homologous Antagonist/Killer (BAK1)

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