Bardet-Biedl Syndrome 4 Protein (BBS4) Antibody

BBS4 Antibody is a Rabbit Polyclonal antibody against BBS4. This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by severe pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse. The similar phenotypes exhibited by mutations in BBS gene family members are likely due to the protein's shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene has sequence similarity to O-linked N-acetylglucosamine (O-GlcNAc) transferases in plants and archaebacteria and in human forms a multi-protein "BBSome" complex with six other BBS proteins. Alternative splice variants have been described but their predicted protein products have not been experimentally verified.

Target	Bardet-Biedl Syndrome 4 Protein (BBS4)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 350-519 of human BBS4.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q96RK4 (UniProt, ExPASy)
UniProt Secondary AC	B4E178, Q53DZ5, Q8NHU9, Q96H45
UniProt Entry Name	BBS4_HUMAN
GeneID	585
NCBI Accession	NP_149017.2
KEGG	hsa:585
String	9606.ENSP00000268057
Molecular Weight	Calculated MW: 58 kDa Observed MW: 53 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Bardet-Biedl Syndrome 4 Protein (BBS4)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue