Basiliximab
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Price:
US$493.00
(Size: 100 µg)
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Basiliximab is a monoclonal antibody biosimilar expressed in CHO cells, targeting IL2RA/CD25, for use in laboratory research applications. This product is not suitable for use as medicines or in human, therapeutic or diagnostic applications.
A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known as CD25 antigen) on the surface of activated T-lymphocytes. It is a 144 kDa glycoprotein obtained from fermentation of an established mouse myeloma cell line genetically engineered to express plasmids containing the human heavy and light chain constant region genes and mouse heavy and light chain variable region genes encoding the RFT5 antibody that binds selectively to the IL-2R alpha. Basiliximab binds with high-affinity to the alpha-subunit (CD25) of the high-affinity IL-2 receptor. This inhibits IL-2 binding, which inhibits T-cell activation and prevents the body from mounting an immune response against the foreign kidney.
Target |
IL2RA/CD25 |
Clonality |
Monoclonal |
Reactivity |
Human |
Expression |
Recombinant |
Tested Applications |
ELISA, WB |
Host |
Human, Mouse |
Recommended dilutions |
Optimal dilutions/concentrations should be determined by the end user. |
Conjugation |
Unconjugated |
Isotype |
IgG1 Kappa |
Form |
Liquid |
Purity |
> 95% |
Purification |
Purified from cell culture supernatants by Protein A/G chromatography. |
Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Buffer |
0.01 M PBS. pH 7.4. |
CAS Number |
179045-86-4 |
Concentration |
Batch-dependent, typically between 0.5-2.0 mg/ml. |
Availability |
Shipped within 7-12 working days. |
Note |
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Research Articles on IL2RA/CD25