B-Cell Lymphoma/leukemia 10 (BCL10) Antibody

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

Target	B-Cell Lymphoma/leukemia 10 (BCL10)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC, IF/ICC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100, IF/ICC: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 24-51 amino acids from the N-terminal region of human BCL10.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O95999 (UniProt, ExPASy)
UniProt Secondary AC	Q5VUF1
UniProt Entry Name	BCL10_HUMAN
Gene Symbol	BCL10
KEGG	hsa:8915
String	9606.ENSP00000359612
Molecular Weight	Calculated MW: 26.3 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat BCL10.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on B-Cell Lymphoma/leukemia 10 (BCL10)

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