Beclin 1 (BECN1) Antibody

Beclin 1 (BECN1) Antibody is a Rabbit Polyclonal antibody for the detection of Beclin 1.

Beclin-1 (BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.

Target	Beclin 1 (BECN1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	beclin 1, autophagy related
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	Q14457 (UniProt, ExPASy)
UniProt Secondary AC	B2R6N7, O75595, Q9UNA8
UniProt Entry Name	BECN1_HUMAN
Gene Symbol	BECN1
GeneID	8678
OMIM	604378
HGNC	1034
KEGG	hsa:8678
Ensembl	ENSG00000126581
String	9606.ENSP00000355231
Molecular Weight	Observed MW: 55 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Beclin 1 (BECN1)

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