Beta-Secretase 1 (BACE1) Antibody

Beta-Secretase 1 (BACE1) Antibody is a Rabbit Polyclonal antibody for the detection of BACE1.

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.

Target	Beta-Secretase 1 (BACE1)
Clonality	Polyclonal
Reactivity	Human, Rat
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	beta-site APP-cleaving enzyme 1
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P56817 (UniProt, ExPASy)
UniProt Secondary AC	A0M8W7, B0YIU9, E9PE65, H7BXJ9, Q9BYB9, Q9BYC0, Q9BYC1, Q9UJT5, Q9ULS1
UniProt Entry Name	BACE1_HUMAN
Gene Symbol	BACE1
GeneID	23621
OMIM	604252
HGNC	933
KEGG	hsa:23621
Ensembl	ENSG00000186318
String	9606.ENSP00000318585
Molecular Weight	Observed MW: 50-55 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Beta-Secretase 1 (BACE1)

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