Myc Box-Dependent-Interacting Protein 1 (BIN1) Antibody

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Catalogue No: abx001484
Price: US$203.00
(Size: 20 µl)

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Datasheet SDS
BIN1 Antibody is a Rabbit Polyclonal antibody against BIN1. This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Target Myc Box-Dependent-Interacting Protein 1 (BIN1)
Clonality Polyclonal
Reactivity Human, Rat
Tested Applications WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/20 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 230-409 of human BIN1.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O00499 (UniProt, ExPASy)
UniProt Entry Name BIN1_HUMAN
Gene Symbol BIN1
GeneID 274
NCBI Accession NP_647601.1
KEGG hsa:274
String 9606.ENSP00000316779
Molecular Weight Calculated MW: 65 kDa
Observed MW: 65 kDa
Buffer PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration > 0.2 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Myc Box-Dependent-Interacting Protein 1 (BIN1)


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