Tyrosine-Protein Kinase BLK (BLK) Antibody

Blk is a Src family protein tyrosine kinase expressed in all stages of B cell development.Activation of B cells by various ligands is accompanied by activation of Blk.It has been suggested that Blk is involved in the control of B cell differentiation and proliferation.Blk transcripts have also been detected in human thymocytes, but not in mature T cells, implicating that Blk may play an important role in thymopoiesis.Blk function may be redundant, however, as mice that do not express Blk are not impaired with respect to B cell development and immune response.

Target	Tyrosine-Protein Kinase BLK (BLK)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IF/ICC, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human BLK expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P51451 (UniProt, ExPASy)
UniProt Secondary AC	Q16291, Q96IN1
UniProt Entry Name	BLK_HUMAN
Gene Symbol	BLK
GeneID	640
OMIM	191305
HGNC	1057
KEGG	hsa:640
Ensembl	ENSG00000136573
String	9606.ENSP00000259089
Molecular Weight	58 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Tyrosine-Protein Kinase BLK (BLK)

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