Polycomb Complex Protein BMI-1 (BMI1) Antibody

Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

Target	Polycomb Complex Protein BMI-1 (BMI1)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC, IF/ICC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/8000, IHC-P: 1/10 - 1/50, IF/ICC: 1/25, FCM: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Human BMI1 recombinant protein.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P35226 (UniProt, ExPASy)
UniProt Secondary AC	Q16030, Q5T8Z3, Q96F37
UniProt Entry Name	BMI1_HUMAN
Gene Symbol	BMI1
KEGG	hsa:100532731 hsa:648
String	9606.ENSP00000473391
Molecular Weight	Calculated MW: 36.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Polycomb Complex Protein BMI-1 (BMI1)

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