Cytoplasmic Tyrosine-Protein Kinase BMX (BMX) Antibody

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Catalogue No: abx015779
Price: US$420.50
(Size: 100 µl)

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Datasheet SDS
BMX (bone marrow X kinase) is a cytoplasmic tyrosine kinase identified by reverse transcription of mRNA isolated from human bone marrow and mapped to the chromosomal band Xp22.2.The full length protein is 675 amino acids with a tyrosine kinase domain, an amino terminal pleckstrin domain, as well as an SH3 and SH2 domain.Direct comparison of BMX's primary sequence with other kinases showed that this is highly related to the family of BTK/ITK/TEC.BMX kinase is expressed in fetal and adult tissues, with the highest expression in heart, testis, small intestine and colon.It is undetectable in spleen, brain, kidney, and pancreas.Further analysis of mRNA expression showed that BMX is expressed in hematopoietic tissues and neutrophilic granulocytes, and in patients with acute and myeloid leukemia.The levels of BMX mRNA were substantially lower in patients with acute and chronic lymphoid leukemias, thus suggesting that BMX may be important during myelopoiesis.CST:It is expressed in a variety of hematopoietic, epithelial and endothelial cells.

Target Cytoplasmic Tyrosine-Protein Kinase BMX (BMX)
Clonality Monoclonal
Reactivity Human
Tested Applications ELISA
Host Mouse
Recommended dilutions ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Purified recombinant fragment of human BMX expressed in E. coli.
Isotype IgG1
Form Liquid
Purification Unpurified ascites.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P51813 (UniProt, ExPASy)
UniProt Secondary AC A6NIH9, O60564, Q12871
UniProt Entry Name BMX_HUMAN
Gene Symbol BMX
GeneID 660
OMIM 300101
HGNC 1079
KEGG hsa:660
Ensembl ENSG00000102010
String 9606.ENSP00000350224
Molecular Weight 78 kDa
Buffer Ascitic fluid containing 0.03% sodium azide.
Concentration Not determined.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Cytoplasmic Tyrosine-Protein Kinase BMX (BMX)


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