Breast Cancer Type 1 Susceptibility Protein (BRCA1) Antibody
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Catalogue No: abx015781
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US$427.75
(Size: 100 µl)
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Datasheet SDS
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor.The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC).This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes.This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination.Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers.Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described.A related pseudogene, which is also located on chromosome 17, has been identified.
Research Articles on Breast Cancer Type 1 Susceptibility Protein (BRCA1)
| Target | Breast Cancer Type 1 Susceptibility Protein (BRCA1) |
| Research Area | Signal Transduction, Tumor Immunity, Cancer |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IHC |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human BRCA1 (AA: 229-335) expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Purified from ascites by Protein G chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P38398 (UniProt, ExPASy) |
| UniProt Secondary AC | E9PFZ0, O15129, Q1RMC1, Q3LRJ0, Q3LRJ6, Q6IN79, Q7KYU9 |
| UniProt Entry Name | BRCA1_HUMAN |
| Gene Symbol | BRCA1 |
| GeneID | 672 |
| OMIM | 113705 |
| HGNC | 1100 |
| KEGG | hsa:672 |
| Ensembl | ENSG00000012048 |
| String | 9606.ENSP00000418960 |
| Molecular Weight | 207.7 kDa |
| Buffer | PBS, containing 0.05% sodium azide. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |