Breast Cancer Type 1 Susceptibility Protein Phospho-Ser1423 (BRCA1 pS1423) Antibody

BRCA1 (pS1423) Antibody is a Rabbit Polyclonal antibody against BRCA1 (pS1423). This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

Target	Breast Cancer Type 1 Susceptibility Protein Phospho-Ser1423 (BRCA1 pS1423)
Clonality	Polyclonal
Target Modification	Ser1423
Modification	Phosphorylation
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic phosphorylated peptide around S1423 of human BRCA1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P38398 (UniProt, ExPASy)
UniProt Secondary AC	E9PFZ0, O15129, Q1RMC1, Q3LRJ0, Q3LRJ6, Q6IN79, Q7KYU9
UniProt Entry Name	BRCA1_HUMAN
Gene Symbol	BRCA1
GeneID	672
NCBI Accession	NP_009225.1
KEGG	hsa:672
String	9606.ENSP00000418960
Molecular Weight	Calculated MW: 208 kDa Observed MW: 270 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Breast Cancer Type 1 Susceptibility Protein Phospho-Ser1423 (BRCA1 pS1423)

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