Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) Antibody

Catalogue No: abx111254
Price: £275.00
(Size: 50 µl)
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Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) Antibody is a Rabbit Polyclonal antibody against Lys-63-Specific Deubiquitinase BRCC36 (BRCC3). This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.

Target Lys-63-Specific Deubiquitinase BRCC36 (BRCC3)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications ELISA, WB, IHC
Host Rabbit
Recommended dilutions Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Human BRCC3.
Isotype IgG
Form Liquid
Purification Antigen Affinity Chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P46736 (UniProt, ExPASy)
UniProt Secondary AC A6QRF8, A6QRF9, A8MUX5, A8MWH0, A9Z1Y0, A9Z1Y5, B1B062, B4DQN7, Q16107, Q53YX5, Q9BTZ6
UniProt Entry Name BRCC3_HUMAN
Gene Symbol BRCC3
GeneID 79184
OMIM 300617
NCBI Accession NP_001018065.1 NM_001018055.2 NP_001229569.1 NM_001242640.1 NP_077308.1 NM_024332.3
HGNC 24185
KEGG hsa:79184
Ensembl ENSG00000185515
String 9606.ENSP00000358474
Buffer PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) Antibody

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