F-Box/WD Repeat-Containing Protein 1A (BTRC) Antibody

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.

Target	F-Box/WD Repeat-Containing Protein 1A (BTRC)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 17-52 amino acids from the N-terminal region of human BTRC.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9Y297 (UniProt, ExPASy)
UniProt Secondary AC	B5MD49, Q5W141, Q5W142, Q9Y213
UniProt Entry Name	FBW1A_HUMAN
Gene Symbol	BTRC
String	9606.ENSP00000359206
Molecular Weight	Calculated MW: 68.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse BTRC.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on F-Box/WD Repeat-Containing Protein 1A (BTRC)

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