+44 (0) 1223 755950
+1 832 327 7413
E3 Ubiquitin-Protein Ligase CBL (C-CBL) Antibody
REQUEST MORE INFO
Catalogue No: abx011635
Price:
US$420.50
(Size: 100 µl)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.
Research Articles on E3 Ubiquitin-Protein Ligase CBL (C-CBL)
| Target | E3 Ubiquitin-Protein Ligase CBL (C-CBL) |
| Clonality | Monoclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human C-CBL expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P22681 (UniProt, ExPASy) |
| UniProt Secondary AC | A3KMP8 |
| UniProt Entry Name | CBL_HUMAN |
| GeneID | 867 |
| KEGG | hsa:867 |
| String | 9606.ENSP00000264033 |
| Molecular Weight | 120 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |