Complement C5 (C5) Antibody
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Catalogue No: abx034006
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US$326.25
(Size: 80 µl)
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Datasheet SDS
C5 is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components.
Research Articles on Complement C5 (C5)
| Target | Complement C5 (C5) |
| Research Area | Metabolism, Infection Immunity, Immunology, Hematology, Autoimmunity |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 253-281 amino acids from the N-terminal region of human C5. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P01031 (UniProt, ExPASy) |
| UniProt Secondary AC | Q14CJ0, Q27I61 |
| UniProt Entry Name | CO5_HUMAN |
| Gene Symbol | C5 |
| GeneID | 727 |
| OMIM | 120900 |
| HGNC | 1331 |
| KEGG | hsa:727 |
| Ensembl | ENSG00000106804 |
| String | 9606.ENSP00000223642 |
| Molecular Weight | Calculated MW: 188 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |