Cadherin-1 / E-Cadherin (CDH1) Antibody

Catalogue No: abx002263
Price: £200.00
(Size: 50 µl)
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CDH1 Antibody is a Rabbit Polyclonal antibody against CDH1. Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadherin (E-Cad), also known as CDH1 and CD324, is the classical cadherin molecule and contains five cadherin domains of ~110 aa each in the extracellular domain. E-Cad is expressed in the non-neural epithelial tissues as disulfide-linked homodimer, and plays a key role in the organization and integrity of most epithelial tissues, cell differentiation and tissue development. CDH1 interacts directly, via the cytoplasmic domain, with CTNNB1 or JUP to form the PSEN1/cadherin/catenin adhesion complex which connects to the actin skeleton through the actin binding of alpha-catenin. During apoptosis or with calcium influx, E-Cad is cleaved by the metalloproteinase to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. E-Cad has been identified as a potent invasive suppressor, as downregulation of E-cadherin expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas (gastric, breast, ovary, endometrium and thyroid).

Target Cadherin-1 / E-Cadherin (CDH1)
Clonality Polyclonal
Reactivity Mouse
Tested Applications IHC
Host Rabbit
Recommended dilutions IHC: 1/200 - 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of mouse CDH1.
Isotype IgG
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P09803 (UniProt, ExPASy)
UniProt Secondary AC Q61377
UniProt Entry Name CADH1_MOUSE
GeneID 999
KEGG mmu:12550
String 10090.ENSMUSP00000000312
Molecular Weight 98 kDa
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Cadherin-1 / E-Cadherin (CDH1)

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