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Cadherin-1 (CDH1) Antibody
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Catalogue No: abx240004
Price:
US$406.00
(Size: 100 µg)
Orders to United States ship from United States
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Cadherin-1 (CDH1) Antibody is a Mouse Monoclonal antibody for the detection of Cadherin-1. This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
Research Articles on Cadherin-1 (CDH1)
| Target | Cadherin-1 (CDH1) |
| Research Area | Tumour Immunity |
| Clonality | Monoclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Mouse |
| Recommended dilutions | WB: 1/1000 - 1/5000, IHC: 1/500 - 1/2000, IF/ICC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | cadherin 1, type 1, E-cadherin (epithelial) |
| Isotype | IgG2b |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P12830 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K1U7, Q13799, Q14216, Q15855, Q16194, Q4PJ14, Q9UII8 |
| UniProt Entry Name | CADH1_HUMAN |
| Gene Symbol | CDH1 |
| GeneID | 999 |
| OMIM | 119580 |
| HGNC | 1748 |
| KEGG | hsa:999 |
| Ensembl | ENSG00000039068 |
| String | 9606.ENSP00000261769 |
| Molecular Weight | Observed MW: 130 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |