Cell Adhesion Molecule 1 (CADM1) Antibody

Catalogue No: abx001553
Price: £120.00
(Size: 20 µl)
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CADM1 Antibody is a Rabbit Polyclonal antibody against CADM1. Homologous to the poliovirus receptor (PVR/CD155), the Nectin immunoglobulin superfamily comprises four known isoforms, Nectin 1, 2, 3 and 4 (also designated TSLC1). TSLC1 is encoded by a tumor-suppressor gene in human non-small-cell lung cancer mapping to chromosome 11q23.2. The TSLC1 protein is an N-linked membrane glycoprotein that co-localizes with the Actin filament-binding protein, afadin, at cadherin-based adherens junctions in MDCKII epithelial cells. TSLC1 also interacts with the tumor-suppressor gene product DAL-1 (for differentially expressed in adenocarcinoma of the lung protein 1) to target Actin rearragement and cellular motility. TSLC1 may also form homodimers that function in homophilic, intracellular adhesion. TSLC1 expression is reduced or absent in a number of characterized cancer cell lines including A549. In prostate and breast cancer, as well as in pancreatic ductal adenocarcinoma, the TSLC1 promoter is commonly silenced by hypermethylation. Unlike other Nectins, which are more widely expressed, TSLC1 is mainly expressed in the placenta.

Target CADM1
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human CADM1.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q9BY67 (UniProt, ExPASy)
UniProt Entry Name CADM1_HUMAN
Gene Symbol CADM1
GeneID 23705
String 9606.ENSP00000329797
Molecular Weight Calculated MW: 36 kDa, 45 kDa, 48 kDa, 49 kDa, 51 kDa
Observed MW: 67 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on CADM1

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