Calcium/calmodulin-Dependent 3',5'-Cyclic Nucleotide Phosphodiesterase 1B (PDE1B) Antibody

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily.Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex.This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate.cAMP and cGMP function as key regulators of many important physiological processes.Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Target	Calcium/calmodulin-Dependent 3',5'-Cyclic Nucleotide Phosphodiesterase 1B (PDE1B)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IHC, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human PDE1B (AA: 370-536) expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q01064 (UniProt, ExPASy)
UniProt Secondary AC	Q92825, Q96KP3
Gene Symbol	PDE1B
GeneID	5153
OMIM	171891
HGNC	8775
Ensembl	ENSG00000123360
Molecular Weight	61.4 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Calcium/calmodulin-Dependent 3',5'-Cyclic Nucleotide Phosphodiesterase 1B (PDE1B)

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