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Introduction | Calprotectin is a complex of the mammalian proteins S100A8 and S100A9. In the presence of calcium, calprotectin iscapable of sequestering the transition metals manganese and zinc via chelation. This metal sequestration affords the complexantimicrobial properties. Calprotectin is the only known antimicrobial manganese sequestration protein complex. Calprotectincomprises as much as 60% of the soluble protein content of the cytosol of a neutrophil, and it is secreted by an unknown mechanismduring inflammation. Faecal calprotectin has been used to detect intestinal inflammation (colitis or enteritis) and can serve as abiomarker for inflammatory bowel diseases. Other names for calprotectin include MRP8-MRP14, calgranulin A and B, cystic fibrosisantigen, L1, 60BB antigen, and 27E10 antigen. |
Target | Calprotectin |
Reactivity | Dog |
Tested Applications | CLIA |
Recommended dilutions | Optimal dilutions/concentrations should be determined by the end user. |
Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
Validity | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
Stability | The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Test Range | 0.14 ng/ml - 100 ng/ml |
Sensitivity | < 0.05 ng/ml |
Standard Form | Lyophilized |
Detection Method | Chemiluminescent |
Assay Type | Sandwich |
Assay Data | Quantitative |
Sample Type | Serum, plasma and other biological fluids. |
Availability | Shipped within 5-20 working days. |
Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Standard | 50000 ng/ml |