Calreticulin (CALR) Antibody

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Catalogue No: abx016075
Price: US$420.50
(Size: 100 µl)

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Datasheet SDS
Calreticulin, also known as RO, CALR, SSA, cC1qR, FLJ26680, CALR.Entrez Protein NP_004334.It is a multifunctional protein that acts as a major Ca (2+)-binding (storage) protein in the lumen of the endoplasmic reticulum.It is also found in the nucleus, suggesting that it may have a role in transcription regulation.Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors.Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium.The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element.Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation.Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors.Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen.Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven.Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.

Target Calreticulin (CALR)
Clonality Monoclonal
Reactivity Human, Mouse
Tested Applications ELISA, WB, IHC, IF/ICC
Host Mouse
Recommended dilutions ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic peptide corresponding to aa (EEEDVPGQAKDELC) of human Calreticulin, conjugated to KLH.
Isotype IgG2a
Form Liquid
Purification Unpurified ascites.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P27797 (UniProt, ExPASy)
UniProt Secondary AC Q6IAT4, Q9UDG2
UniProt Entry Name CALR_HUMAN
Gene Symbol CALR
GeneID 811
OMIM 109091
NCBI Accession NP_004334.1
HGNC 1455
KEGG hsa:811
Ensembl ENSG00000179218
String 9606.ENSP00000320866
Molecular Weight 48 kDa
Buffer Ascitic fluid containing 0.03% sodium azide.
Concentration Not determined.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Calreticulin (CALR)


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