Calpain-1 Catalytic Subunit (CAPN1) Antibody

CAPN1 Antibody is a Rabbit Polyclonal antibody against CAPN1. The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene.

Target	Calpain-1 Catalytic Subunit (CAPN1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 355-530 of human Calpain 1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P07384 (UniProt, ExPASy)
UniProt Secondary AC	Q2TTR0, Q6DHV4
UniProt Entry Name	CAN1_HUMAN
Gene Symbol	CAPN1
GeneID	823
NCBI Accession	NP_005177.2
KEGG	hsa:823
String	9606.ENSP00000431984
Molecular Weight	Calculated MW: 82 kDa Observed MW: 75-80 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Calpain-1 Catalytic Subunit (CAPN1)

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