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Caspase Recruitment Domain Family Member 8 (CARD8) Antibody

Catalogue No: abx000674
Price: £120.00
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Caspase Recruitment Domain Family Member 8 (CARD8) Antibody

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CARD8 Antibody is a Rabbit Polyclonal antibody against CARD8. The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq].

Target CARD8
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human CARD8.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q9Y2G2 (UniProt, ExPASy)
UniProt Secondary AC B5KVR6, B7Z496, B7Z4A2, E9PEM7, G3XAM9, Q6PGP8, Q96P82
UniProt Entry Name CARD8_HUMAN
Gene Symbol CARD8
GeneID 22900
String 9606.ENSP00000375767
Molecular Weight Calculated MW: 32 kDa, 44 kDa, 48 kDa, 55 kDa, 60 kDa
Observed MW: 55 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Caspase Recruitment Domain Family Member 8 (CARD8) Antibody

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