Caspase 3 (CASP3) Antibody
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Catalogue No: abx000602
Price:
US$348.00
(Size: 60 µl)
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Datasheet SDS
CASP3 Antibody is a Rabbit Polyclonal antibody against CASP3. This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Research Articles on Caspase 3 (CASP3)
| Target | Caspase 3 (CASP3) |
| Research Area | Signal Transduction, Enzymes and Kinases, Apoptosis, Tumor Immunity, Infection Immunity, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to human Caspase-3 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P42574 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K5M2, D3DP53, Q96AN1, Q96KP2 |
| UniProt Entry Name | CASP3_HUMAN |
| Gene Symbol | CASP3 |
| GeneID | 836 |
| NCBI Accession | NP_004337.2 |
| KEGG | hsa:836 |
| String | 9606.ENSP00000311032 |
| Molecular Weight | Calculated MW: 31 kDa Observed MW: 15 kDa/35 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-7 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
