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Caspase 3 (CASP3) Antibody

Catalogue No: abx000602
Price: £120.00
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Caspase 3 (CASP3) Antibody Caspase 3 (CASP3) Antibody Caspase 3 (CASP3) Antibody

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CASP3 Antibody is a Rabbit Polyclonal antibody against CASP3. This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Target CASP3
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide corresponding to a sequence within aminoacids 100-200 of human Caspase 3.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P42574 (UniProt, ExPASy)
UniProt Secondary AC A8K5M2, D3DP53, Q96AN1, Q96KP2
UniProt Entry Name CASP3_HUMAN
Gene Symbol CASP3
GeneID 836
NCBI Accession NP_004337.2
KEGG hsa:836
String 9606.ENSP00000311032
Molecular Weight Calculated MW: 31 kDa
Observed MW: 15 kDa, 35 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration 2.86 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Caspase 3 (CASP3) Antibody

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