Caspase 8 (CASP8) Antibody
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Catalogue No: abx012068
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US$427.75
(Size: 100 µl)
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Datasheet SDS
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Alternative splicing of this gene results in five transcript variants.
Research Articles on Caspase 8 (CASP8)
| Target | Caspase 8 (CASP8) |
| Research Area | Signal Transduction, Enzymes and Kinases, Apoptosis, Tumor Immunity, Neuroscience, Cancer |
| Clonality | Monoclonal |
| Reactivity | Human, Mouse, Monkey, Rat |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human CASP8 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q14790 (UniProt, ExPASy) |
| UniProt Entry Name | CASP8_HUMAN |
| GeneID | 841 |
| KEGG | hsa:841 |
| String | 9606.ENSP00000351273 |
| Enzyme Commission Number | EC 3.4.22.- EC 3.4.22.61 |
| Molecular Weight | 26 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |