Human Caspase-14 (CASP14) Protein (Active)

Human Caspase-14 (CASP14) Protein is a recombinant Human protein expressed in E. coli.

Caspase-14 (CASP14) is a member of the caspase family. Caspases are cysteine proteinases consisting of a prodomain plus large and small catalytic subunits and are involved in cell apoptosis. Caspase-14 (CASP14) has an unusually short prodomain and is highly expressed in embryonic tissues but absent from most of the adult tissues except for the skin, which suggests a role in ontogenesis and skin physiology. Unlike the other short prodomain caspases, (Caspase-3, Caspase-6 and Caspase-7), Caspase 14 is not processed by death stimuli including activation of members of the tumor necrosis factor receptor family and expression of proapaptotic members of the bcl-2 family. It is processed and activated by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may take part in keratinocyte terminal differentiation, which is essential for the skin barrier.

Target	Caspase-14 (CASP14)
Research Area	Enzymes and Kinases
Origin	Human
Expression	Recombinant
Tested Applications	SDS-PAGE
Host	E. coli
Form	Liquid
Activity	Active
Purity	> 98.2% (SDS-PAGE)
Storage	Aliquot and store at < -20°C. Avoid repeated freeze/thaw cycles.
Shelf Life	6 months.
UniProt Primary AC	P31944 (UniProt, ExPASy)
UniProt Secondary AC	O95823, Q3SYC9
UniProt Entry Name	CASPE_HUMAN
Gene Symbol	CASP14
GeneID	23581
NCBI Accession	NP_036246.1
KEGG	hsa:23581
String	9606.ENSP00000393417
Molecular Weight	Calculated MW: 28.5 kDa Observed MW: 30 kDa (SDS-PAGE)
Sequence Fragment	Ser2-Gln242
Tag	N-terminal His tag
Buffer	Sterile PBS, pH 7.4.
Endotoxin Level	< 1.0 EU per µg as determined by the LAL method.
Concentration	0.7 mg/ml
Availability	Shipped within 5-15 working days.
Note	THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Directions for use	Centrifuge before opening to ensure complete recovery of vial contents.

Research Articles on Caspase-14 (CASP14)

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