Caspase 3 (CASP3) Antibody

Caspase 3 (CASP3) Antibody is a Rabbit Polyclonal antibody for the detection of Caspase 3.

Caspase 3, also named as CPP32, SCA-1 and Apopain, belongs to the peptidase C14A family. Caspase 3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly (ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Caspase 3 cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6,-7 and-9. Caspase 3 is involved in the cleavage of huntingtin. The antibody can recognize p17 and p32 of Caspase 3.

Target	Caspase 3 (CASP3)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/200 - 1/2000, IHC: 1/50 - 1/500, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	caspase 3, apoptosis-related cysteine peptidase
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P42574 (UniProt, ExPASy)
UniProt Secondary AC	A8K5M2, D3DP53, Q96AN1, Q96KP2
UniProt Entry Name	CASP3_HUMAN
Gene Symbol	CASP3
GeneID	836
OMIM	600636
HGNC	1504
KEGG	hsa:836
Ensembl	ENSG00000164305
String	9606.ENSP00000311032
Molecular Weight	Observed MW: 32-35 kDa, 17 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Caspase 3 (CASP3)

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