Calcium Sensing Receptor (CASR) Antibody
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Catalogue No: abx031413
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US$326.25
(Size: 80 µl)
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Datasheet SDS
The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH) producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq].
Research Articles on Calcium Sensing Receptor (CASR)
| Target | Calcium Sensing Receptor (CASR) |
| Research Area | Metabolism, Endocrinology, Neuroscience, Hormone Metabolism |
| Clonality | Polyclonal |
| Reactivity | Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 260-287 amino acids from the Central region of human CASR. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P41180 (UniProt, ExPASy) |
| UniProt Secondary AC | Q13912, Q16108, Q16109, Q16110, Q16379, Q2M1T0, Q4PJ19 |
| UniProt Entry Name | CASR_HUMAN |
| Gene Symbol | CASR |
| KEGG | hsa:846 |
| String | 9606.ENSP00000420194 |
| Molecular Weight | Calculated MW: 121 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rat, Cow and Pig CASR. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |