Cathepsin B (CATB) Antibody

The protein CATB is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors.

Target	Cathepsin B (CATB)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 198-227 amino acids from the Central region of human CATB.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P07858 (UniProt, ExPASy)
UniProt Secondary AC	B3KQR5, B3KRR5, Q503A6, Q96D87
UniProt Entry Name	CATB_HUMAN
KEGG	hsa:1508
String	9606.ENSP00000345672
Molecular Weight	Calculated MW: 37.8 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Monkey CTSB.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Cathepsin B (CATB)

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