Chromobox Protein Homolog 5 (CBX5) Antibody

Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (By similarity).

Target	Chromobox Protein Homolog 5 (CBX5)
Clonality	Polyclonal
Reactivity	Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 160-186 amino acids from the C-terminal region of mouse Cbx5.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q61686 (UniProt, ExPASy)
UniProt Secondary AC	Q9CS35, Q9CXD1
UniProt Entry Name	CBX5_MOUSE
KEGG	mmu:12419
String	10090.ENSMUSP00000113157
Molecular Weight	Calculated MW: 22.2 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Human Cbx5.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Chromobox Protein Homolog 5 (CBX5)

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