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C-C Motif Chemokine 2 / MCP1 (CCL2) Antibody
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Catalogue No: abx012194
Price:
US$427.75
(Size: 100 µl)
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This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.
Research Articles on C-C Motif Chemokine 2 / MCP1 (CCL2)
| Target | C-C Motif Chemokine 2 / MCP1 (CCL2) |
| Clonality | Monoclonal |
| Reactivity | Human, Mouse, Monkey |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human CCL2 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Purified from ascites by Protein G chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P13500 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R4V3, Q9UDF3 |
| UniProt Entry Name | CCL2_HUMAN |
| Gene Symbol | CCL2 |
| GeneID | 6347 |
| OMIM | 158105 |
| NCBI Accession | NP_002973.1 NM_002982.3 |
| HGNC | 10618 |
| KEGG | hsa:6347 |
| Ensembl | ENSG00000108691 |
| String | 9606.ENSP00000225831 |
| Molecular Weight | 11 kDa |
| Buffer | PBS, containing 0.05% sodium azide. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |