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C-C Motif Chemokine 5 (CCL5) Antibody
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Catalogue No: abx004305
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US$217.50
(Size: 20 µl)
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Datasheet SDS
CCL5 Antibody is a Rabbit Polyclonal antibody against CCL5. This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms.
Research Articles on C-C Motif Chemokine 5 (CCL5)
| Target | C-C Motif Chemokine 5 (CCL5) |
| Research Area | Cytokines, Tumor Immunity, Infection Immunity, Immune Molecule, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-91 of human CCL5/RANTES. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P13501 (UniProt, ExPASy) |
| UniProt Secondary AC | O43646, Q0QVW8, Q4ZGJ1, Q9NYA2, Q9UBG2, Q9UC99 |
| UniProt Entry Name | CCL5_HUMAN |
| Gene Symbol | CCL5 |
| GeneID | 6352 |
| NCBI Accession | NP_002976.2 |
| KEGG | hsa:6352 |
| String | 9606.ENSP00000474412 |
| Molecular Weight | Calculated MW: 10 kDa Observed MW: 13 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |