CCNA1 Antibody is a Rabbit Polyclonal antibody against CCNA1. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene.

Target	Cyclin A1 (CCNA1)
Clonality	Polyclonal
Reactivity	Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to human CCNA1
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P78396 (UniProt, ExPASy)
UniProt Secondary AC	B7Z7E3, Q5T3V0, Q5U0G2, Q8IY91
UniProt Entry Name	CCNA1_HUMAN
Gene Symbol	CCNA1
GeneID	8900
NCBI Accession	NP_001104515.1
KEGG	hsa:8900
String	9606.ENSP00000255465
Molecular Weight	Calculated MW: 47 kDa/52 kDa Observed MW: 52 kDa
Buffer	PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Research Articles on Cyclin A1 (CCNA1)

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