Cyclin D1 (CCND1) Antibody
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Catalogue No: abx011703
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US$427.75
(Size: 100 µl)
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Datasheet SDS
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
Research Articles on Cyclin D1 (CCND1)
| Target | Cyclin D1 (CCND1) |
| Research Area | Tumor Immunity, Developmental Science, Cancer |
| Clonality | Monoclonal |
| Clone | K280 |
| Reactivity | Human |
| Tested Applications | ELISA |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000. WB: 1/500-1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of Human CCND1 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P24385 (UniProt, ExPASy) |
| UniProt Secondary AC | Q6LEF0 |
| UniProt Entry Name | CCND1_HUMAN |
| Gene Symbol | CCND1 |
| GeneID | 595 |
| OMIM | 168461 |
| HGNC | 1582 |
| KEGG | hsa:595 |
| Ensembl | ENSG00000110092 |
| String | 9606.ENSP00000227507 |
| Molecular Weight | 33.7 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |