Cyclin D1 (CCND1) Antibody

Catalogue No: abx001183
Price: £160.00
(Size: 20 µl)
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CCND1 Antibody is a Rabbit Polyclonal antibody against CCND1. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Target CCND1
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IF/ICC, IP
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200, IP: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human Cyclin D1.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P24385 (UniProt, ExPASy)
UniProt Secondary AC Q6LEF0
UniProt Entry Name CCND1_HUMAN
Gene Symbol CCND1
GeneID 595
KEGG hsa:595
String 9606.ENSP00000227507
Molecular Weight Calculated MW: 33 kDa
Observed MW: 34 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on CCND1

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