G1/S-Specific Cyclin-D2 (CCND2) Antibody

CCND2 Antibody is a Rabbit Polyclonal antibody against CCND2. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.

Target	G1/S-Specific Cyclin-D2 (CCND2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-289 of human Cyclin D2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P30279 (UniProt, ExPASy)
UniProt Secondary AC	A8K531, Q13955, Q5U035
UniProt Entry Name	CCND2_HUMAN
Gene Symbol	CCND2
GeneID	894
NCBI Accession	NP_001750.1
KEGG	hsa:894
String	9606.ENSP00000261254
Molecular Weight	Calculated MW: 33 kDa Observed MW: 34 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on G1/S-Specific Cyclin-D2 (CCND2)

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