G1/S-Specific Cyclin-D2 (CCND2) Antibody
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Catalogue No: abx001471
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US$348.00
(Size: 60 µl)
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Datasheet SDS
CCND2 Antibody is a Rabbit Polyclonal antibody against CCND2. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.
Research Articles on G1/S-Specific Cyclin-D2 (CCND2)
| Target | G1/S-Specific Cyclin-D2 (CCND2) |
| Research Area | Tumor Immunity, Developmental Science, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | IF/ICC |
| Host | Rabbit |
| Recommended dilutions | IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human Cyclin D2 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P30279 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K531, Q13955, Q5U035 |
| UniProt Entry Name | CCND2_HUMAN |
| Gene Symbol | CCND2 |
| GeneID | 894 |
| NCBI Accession | NP_001750.1 |
| KEGG | hsa:894 |
| String | 9606.ENSP00000261254 |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
