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Cyclin D3 (CCND3) Antibody
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Catalogue No: abx001007
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US$377.00
(Size: 60 µl)
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Datasheet SDS
CCND3 Antibody is a Rabbit Polyclonal antibody against CCND3. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.
Research Articles on Cyclin D3 (CCND3)
| Target | Cyclin D3 (CCND3) |
| Research Area | Tumor Immunity, Developmental Science, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human CCND3 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P30281 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RD63, B3KQ22, E9PAS4, E9PB36, Q5T8J0, Q6FG62, Q96F49 |
| UniProt Entry Name | CCND3_HUMAN |
| Gene Symbol | CCND3 |
| GeneID | 896 |
| NCBI Accession | NP_001751.1 |
| KEGG | hsa:896 |
| String | 9606.ENSP00000362082 |
| Molecular Weight | Calculated MW: 9 kDa/22 kDa/24 kDa/32 kDa Observed MW: 36 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
