G1/S-Specific Cyclin-E1 Phospho-Thr395 (CCNE1 pT395) Antibody

Catalogue No: abx000102
Price: £120.00
(Size: 20 µl)
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CCNE1 (pT395) Antibody is a Rabbit Polyclonal antibody against CCNE1 (pT395). The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.

Target G1/S-Specific Cyclin-E1 Phospho-Thr395 (CCNE1 pT395)
Clonality Polyclonal
Target Modification Thr395
Modification Phosphorylation
Reactivity Human, Mouse, Rat
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding T395 of human CCNE1.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P24864 (UniProt, ExPASy)
UniProt Secondary AC A8K684, Q14091, Q8NFG1, Q92501, Q9UD21
UniProt Entry Name CCNE1_HUMAN
Gene Symbol CCNE1
GeneID 898
KEGG hsa:898
String 9606.ENSP00000262643
Molecular Weight Calculated MW: 41 kDa, 45 kDa, 47 kDa
Observed MW: 55 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on G1/S-Specific Cyclin-E1 Phospho-Thr395 (CCNE1 pT395)

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