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Cyclin-T1 (CCNT1) Antibody

Catalogue No: abx001674
Price: £120.00
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Cyclin-T1 (CCNT1) Antibody

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CCNT1 Antibody is a Rabbit Polyclonal antibody against CCNT1. This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants.

Target CCNT1
Clonality Polyclonal
Reactivity Human
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human CCNT1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O60563 (UniProt, ExPASy)
UniProt Secondary AC A9XU13, E7EX76, O60581
UniProt Entry Name CCNT1_HUMAN
Gene Symbol CCNT1
GeneID 904
KEGG hsa:904
String 9606.ENSP00000261900
Molecular Weight Calculated MW: 21 kDa, 80 kDa
Observed MW: 81 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Cyclin-T1 (CCNT1) Antibody

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